Cormag+TM was formulated by the research doctors and scientists at Scweitzz, Inc. to promote energy and improve healthy cell function and was based on many years of clinical use and scientific research. It is specifically designed to support synergistically improve and restore cardiovascular function and promote cellular energy and healthy cellular function. The natural and safe ingredients in Commag+ ( hypoxanthine riboside, magnesium citrate and magnesium oxide blend, 100% of the Daily Value of Vitamins B1, B2, B3, B6and D3) work synergistically to enhance and restore cardiovascular integrity and promote mitochondrial activity. The cells’ mitochondria are the furnaces that produce all the energy required for healthy functioning. In the United States both hypoxanthine riboside and magnesium are considered to be GRAS(Generally Recognized As Safe) materials and therefore have been determined to be totally safe for human consumption.
Cormag+TM has diverse mechanisms of action including the following;
• The major ingredients are precursors of the basic energy molecule ATP. Providing these essential substrates improves every aspect of heart as well as general health.
• Positive inotropic agent providing more efficient myocardial contractility (heart pumping action) and thereby improving left ventricular ejection fraction.
• Maintains normal blood flow improving (perfusion) to cardiovascular circulation.
• Mitochondrial function and structure are enhanced resulting in greatly improved cardiac activity.
• Supports healthy heart rhythm.
• Supports healthy bone density.
• Supports a healthy immune system.
• Supports energy production, reduces fatigue and maintains healthy cell function.
***A deficit of ATP is associated with virtually every dysfunction.
Hypoxanthine riboside is the precursor of the basic energy molecule called ATP which enables normal functioning of every organ including the heart, lung, brain and kidney and skeletal muscles. Hypoxanthine riboside has supporting its cardio protective/cardio restorative, neuro protective/neuro restorative and energizing effects and diminishing fatigue in fibromyalgia and chronic fatigue. Hypoxanthine riboside is purine nucleoside found in plants and animals and is the precursor of the basic energy molecule called ATP which enables normal functioning of every organ including the heart, lung, brain and kidney and skeletal muscles. A deficit of ATP is associated with virtually every dysfunction. Hypoxanthine riboside has an extensive literature database supporting its cardio protective/cardio restorative, neuro protective/neuro restorative and energizing effects. The actions of Hypoxanthine riboside’s cardiovascular effects are diverse and include the following: improved heart-pumping action, anti-ischemic/ anti-hypoxic effect, cellular and extra- cellular regeneration effect, coronary vasodilation activity, increasing nucleic acid and protein production and restoration of normal gene expression.
Research supports the theory of hypoxanthine riboside’s ability to restore ventricular heart –pump function and structure by preventing the loss of the effective contractile proteins in the myocyte(muscle cell) and restoring normal cell structure. The end stage of congestive heart failure is characterized by anatomic remodeling from the concentric form of heart hypertrophy (CHH) to the eccentric form of heart hypertrophy (EHH). EHH is accompanied by morphological (cell loss) and biochemical changes (cardio-myofibrils are depleted of the normal α-myosin heavy chain and instead replaced with the non-functional β-myosin heavy chain). This pathologic remodeling leads to mechanical insufficiency and the depression of heart pump performance (ventricular ejection fraction).
Hypoxanthine Riboside contributes to the high energy phosphate pool(ATP) of cardiac muscle cells and favorably affects bioenergetics generally. Hypoxanthine Riboside also enhances the myocardial uptake of carbohydrates relative to free fatty acids as well as glycolysis. It is this property of hypoxanthine riboside which may be responsible for its anabolism action in enhancing exercise and athletic performance and diminishing fatigue in fibromyalgia and chronic fatigue. Hypoxanthine Riboside’s neuro-restorative properties are based upon its documented axon-promoting effects in vivo following transection of the corticospinal tracts of rats and axotomy of gold fish retinal ganglion cells. Inosine may also serve as a nerve growth factor or actually augment neuritogenesis to restore essential neuronal circuitry after CNS injury.
Magnesium Citrate is a highly absorbable form of magnesium which is needed for more then three hundred biochemical reaction in the body which supports muscle contraction and helps to relax muscles and to maintain an already normal blood flow. It can also support a steady heart rhythm and a healthy immune system and supports a healthy bone structure. Magnesium is involved as a co-factor in the cellular energy chain of the Krebs cycle which is essential for the production of cellular energy. A lack of this essential mineral prevents optimal energy utilization by the body and results in organ dysfunction and its sequel. The citrate molecule has also been shown to support normal kidney function and reduce the risk of stones.
Vitamin D is universally acclaimed as critical for generalized well being and is implicated in the healthy functioning of every organ. The recent study in the January 2008 journal of the American Heart Association reported an inverse association of cardiovascular problem and Vitamin D. Therefore, a higher blood level is associated with greater health. Studies evaluating vitamin D’s effects on immune and almost all organ function has yielded similar results. In fact, in light of this research, the US regulatory agencies have increased the recommended daily values for this wonderful vitamin.
The B complex vitamins have long been recognized as essential for the healthy functioning of the human body. In Cormag+ we have included 100% of the daily value for each vitamins. It’s inclusion in this formulation was to specifically optimize energy production in the furnace of the cell called the mitochondrion. One of the many uses of the B Vitamins is to act as coenzymes in the production of the energy molecule ATP.